离子电导与实验性诱发的肌强直。

Ionic conductance and experimentally induced myotonia.

作者信息

Iyer V G, Ranish N A, Fenichel G M

出版信息

J Neurol Sci. 1981 Feb;49(2):159-64. doi: 10.1016/0022-510x(81)90075-7.

Abstract

Experiments were conducted to study the effect of altering external potassium on in vitro induction of myotonia in rat diaphragm using 2,4-dichlorophenoxy acetate (2,4-D). An increase in external potassium inhibited, while a decrease enhanced, the myotonic response. However, in preparations which have undergone prior denervation, there was no myotonic response to 2,4-D, even when the external potassium was lowered. The experiments also support the existence of neural factors influencing the resting ionic conductance of the muscle membrane.

摘要

进行了实验，以研究使用2,4-二氯苯氧乙酸（2,4-D）改变细胞外钾对大鼠膈肌体外诱导肌强直的影响。细胞外钾增加会抑制肌强直反应，而降低则会增强该反应。然而，在先前已去神经的标本中，即使细胞外钾降低，对2,4-D也没有肌强直反应。这些实验还支持存在影响肌膜静息离子电导的神经因素。