Iyer V, Ranish N A, Fenichel G M
Neurology. 1977 Jul;27(7):669-71. doi: 10.1212/wnl.27.7.669.
In order to study the influence of innervation on myotonia, an attempt was made to induce myotonia in previously denervated rat hemidiaphragm preparations in vitro with use of 2,4-dichlorophenoxy acetic acid (2,4-D) and low chloride solutions. Prior denervation prevented the onset of myotonia in both media except during the first 24 hours after nerve section. On the basis of already available data, we propose that the reduced potassium conductance accompanying denervation may be the main factor preventing induciton of myotonia in denervated muscle.
为了研究神经支配对肌强直的影响，人们尝试在体外对预先去神经支配的大鼠半膈肌制备物使用2,4-二氯苯氧乙酸（2,4-D）和低氯溶液来诱导肌强直。除了在神经切断后的最初24小时内，预先去神经支配可防止在两种介质中出现肌强直。基于已有的数据，我们提出去神经支配伴随的钾电导降低可能是防止去神经肌肉中诱导肌强直的主要因素。
