Ptak W, Rewicka M, Bielecka J
J Clin Lab Immunol. 1981 Mar;5(2):121-4.
The expression of Fc receptors (FcR) on macrophage surfaces is dependent on the in vitro insulin level. Macrophages (Mø) of alloxan-diabetic animals have more FcR and phagocytose heavily opsonized sheep erythrocytes (SRBC) better, than normal Mø. The reverse is, however, true when suboptimally opsonized SRBC are used. No differences were found between normal and diabetic macrophages in the rate of catabolism of engulfed antigen. We regard it likely that the generation and/or transmission of Fc-dependent signal from the cell surfaces may be impaired in hypoinsulinaemic environment.
巨噬细胞表面Fc受体（FcR）的表达取决于体外胰岛素水平。与正常巨噬细胞相比，四氧嘧啶糖尿病动物的巨噬细胞具有更多的FcR，并且能更好地吞噬高度调理的绵羊红细胞（SRBC）。然而，当使用次优调理的SRBC时，情况则相反。在吞噬抗原的分解代谢速率方面，正常巨噬细胞和糖尿病巨噬细胞之间未发现差异。我们认为，在低胰岛素血症环境中，细胞表面Fc依赖性信号的产生和/或传递可能受损。
