Abrass C K
Clin Exp Immunol. 1984 Jul;57(1):17-24.
Circulating immune complexes (CIC) have been postulated to contribute to the development of secondary complications in diabetes mellitus. In this study, CIC were measured in control rats and both insulin deficient and insulin treated streptozotocin-induced diabetic rats. CIC were more prevalent in both groups of diabetic rats as determined by the fluid and solid phase Clq binding assays. By 42 days after induction of diabetes, 80% of insulin deficient and 50% of insulin treated rats had detectable CIC by either/or both assays. As determined by direct immunofluorescence, there was progressive accumulation of rat IgG in the glomerular mesangium. The presence of CIC paralleled the glomerular deposition of IgG. The relationship of circulating insulin levels to the clearance of CIC and the glomerular deposition of IgG is discussed.
循环免疫复合物（CIC）被认为与糖尿病继发并发症的发生有关。在本研究中，对正常大鼠、胰岛素缺乏型和胰岛素治疗型链脲佐菌素诱导的糖尿病大鼠的CIC进行了检测。通过液相和固相Clq结合试验测定，两组糖尿病大鼠中CIC更为普遍。糖尿病诱导后42天，80%的胰岛素缺乏型大鼠和50%的胰岛素治疗型大鼠通过其中一种或两种试验可检测到CIC。通过直接免疫荧光法测定，大鼠IgG在肾小球系膜中逐渐积累。CIC的存在与IgG在肾小球的沉积平行。本文讨论了循环胰岛素水平与CIC清除及IgG在肾小球沉积的关系。
