Awad El Karim M A, Collins K J, Sukkar M Y, Omer A H, Amin M A, Doré C
J Trop Med Hyg. 1981 Apr;84(2):67-72.
Acting as their own controls, village subjects from the Gezira are of the Sudan with relatively high levels of schistosomiasis infection were first tested in an exercise laboratory in Khartoum and the tests were then repeated after a period of about 1 yr during which time the subjects were treated with hycanthone and periodically monitored to ensure that they had remained free of the disease. In the meantime they were also given anti-malarial prophylaxis. Laboratory tests showed a significant improvement in physiological work capacity of up to 20% after treatment compared with untreated controls. An overall improvement in pulmonary function, particularly forced vital capacity, was observed as well as a significant increase in mean haemoglobin concentration by 1.1 g/100 ml of blood in the treated group. Apart from these improvements in physical working capacity, the treated subjects subjectively felt better after the exercise tests, as expressed by the disappearance of fatiguability.
来自苏丹杰济拉地区、血吸虫病感染率相对较高的村民作为自身对照，首先在喀土穆的一个运动实验室进行测试，然后在大约1年的时间后重复测试，在此期间，受试者接受海恩酮治疗，并定期监测以确保他们没有感染该疾病。与此同时，他们还接受了疟疾预防治疗。实验室测试表明，与未治疗的对照组相比，治疗后生理工作能力显著提高，最高可达20%。观察到肺功能总体有所改善，尤其是用力肺活量，治疗组的平均血红蛋白浓度也显著增加，每100毫升血液增加1.1克。除了身体工作能力的这些改善外，治疗后的受试者在运动测试后主观感觉更好，表现为疲劳感消失。
