Hacihanefioğlu U
J Bone Joint Surg Am. 1978 Dec;60(8):1131-5.
Clinicopathological observations of eleven cases of tumoral calcinosis are reported. All of the cases showed characteristic clinical and histopathological features of this unusual condition, but pathological findings did not elucidate all of its etiology and pathogenesis. Two of the patients were related. One of the patients showed skeletal changes characterized by diffuse calcium deposits with widespread soft-tissue calcification. The available data of the present study also led to the suggestion that the disease has a genetic background and that the primary defect may well be in the collagen which undergoes calcification.
报告了11例肿瘤性钙化症的临床病理观察结果。所有病例均表现出这种罕见病症的特征性临床和组织病理学特征，但病理结果并未阐明其所有病因和发病机制。其中两名患者有亲属关系。一名患者表现出骨骼改变，其特征为弥漫性钙沉积伴广泛的软组织钙化。本研究的现有数据还表明，该疾病具有遗传背景，主要缺陷很可能在于发生钙化的胶原蛋白。
