Sivamani S, Garg B R, Lal S
Lepr India. 1981 Jan;53(1):45-51.
Status of non-specific cell mediated immunity in 49 leprosy patients classified according to Ridley & Jopling scale and 16 non leprous controls was studied using epicutaneous sensitization with DNCB and quantitatively grading the degree of sensitization with DNCB and quantitatively grading the degree of sensitization and Mx. test with 1 TU PPD. The effect of dapsone administration on CMI responses was also observed. There was no gross depression of CMI responses as made out by epicutaneous sensitization to DNCB but quantitative grading of responses revealed a subtle depression of CMI responses progressively increasing from II to LL end of spectrum. Mx. testing with 1 Tu PPD did not appear to be a good parameter to study the CMI status. Dapsone administration did not alter the CMI responses.
对49例根据里德利和乔普林量表分类的麻风病患者以及16例非麻风对照者的非特异性细胞介导免疫状态进行了研究，采用二硝基氯苯（DNCB）进行表皮致敏，并对致敏程度进行定量分级，同时用1结核菌素单位（TU）的结核菌素纯蛋白衍生物（PPD）进行Mx试验。还观察了氨苯砜给药对细胞介导免疫反应的影响。通过对DNCB的表皮致敏并未发现细胞介导免疫反应有明显抑制，但反应的定量分级显示细胞介导免疫反应有细微抑制，从光谱的Ⅱ型到LL型逐渐增加。用1 TU PPD进行Mx试验似乎不是研究细胞介导免疫状态的良好参数。氨苯砜给药并未改变细胞介导免疫反应。
