[Effect of inhibitors of mitochondrial protein synthesis on the growth of Endomyces magnusii cells].

The purpose of this work was to study the role of the glycolytic system in maintaining the growth and division of Endomyces magnusii cells. The system of oxidative phosphorylation was blocked by adding the inhibitor of mitochondrial translation, erythromycin, and the inhibitor of mitochondrial transcription, ethidium bromide, to the cultural broth. The two inhibitors of mitochondrial protein synthesis entirely prevented the growth and division of yeast cells in liquid and solid media when either fermentable or nonfermentable substrates were used as carbon sources. Two conclusions have been drawn: (1) glycolysis cannot support the growth of Endomyces magnusii cells and (2) the system of oxidative phosphorylation plays an important role in the energy metabolism of this organism.