Calabrese E, Sacco C, Moore G, DiNardi S
Med Hypotheses. 1981 Feb;7(2):133-45. doi: 10.1016/0306-9877(81)90110-9.
It has been hypothesized that sulfite oxidase deficient persons may be at increased risk to toxicity from SO2 and dietary sulfites widely used for food preservation. Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Human and animal studies have shown that S-sulfonates, believed to transport sulfite in the blood, are formed in response to exposure to low levels of SO2. Besides its numerous toxic effects, e.g. respiratory impairment, interference with immunological response and oxygen transport and platelet aggregation inhibition, SO2 has the ability to alter DNA during replication causing T . A transitions, chromosome abnormalities and depression of DNA synthesis.
据推测，亚硫酸盐氧化酶缺乏的人可能因二氧化硫和广泛用于食品保鲜的膳食亚硫酸盐而面临更高的中毒风险。亚硫酸盐氧化酶被认为负责将二氧化硫和/或亚硫酸盐解毒为硫酸盐以便排出体外。人和动物研究表明，据信在血液中运输亚硫酸盐的S-磺酸盐是在接触低水平二氧化硫后形成的。除了其众多毒性作用，如呼吸功能损害、干扰免疫反应、氧气运输以及抑制血小板聚集外，二氧化硫还能够在复制过程中改变DNA，导致T.A转换、染色体异常以及DNA合成受抑制。
