Hamilton M A, Vomachka A J, Lisk R D, Gorski R A
Neuroendocrinology. 1981 Apr;32(4):234-41. doi: 10.1159/000123165.
To localize the neural sites of hormone action for sexual differentiation in the hamster, pellets containing 3 microgram testosterone were implanted directly in the preoptic area-anterior hypothalamus (POA-AH) and the ventromedial hypothalamus-arcuate regions of the hypothalamus of 3-day-old female hamsters. The POA-AH implants strongly enhanced the potential for ectopic mounts, rear mounts, and intromission patterns after adult testosterone treatment. 50% of the females with neonatal POA-AH implants demonstrated vaginal acyclicity in adulthood, suggesting a significant disruption of normal gonadotropin release. Tests for female sexual behavior revealed that implants in both POA-AH and ventromedial arcuate had no significant effect on latency to lordosis or total lordosis duration with estrogen and progesterone priming, but did reduce the longest single bout of lordosis. In conjunction with other recent investigations, these findings suggest that in the hamster, as in other species, androgenization involves several independent processes in terms of both location and sensitivity to hormone exposure.
为了确定仓鼠性别分化中激素作用的神经位点，将含有3微克睾酮的药丸直接植入3日龄雌性仓鼠的视前区 - 下丘脑前部（POA - AH）以及下丘脑腹内侧 - 弓状区域。成年后接受睾酮治疗后，POA - AH植入物显著增强了异位骑跨、后骑跨和插入行为模式的可能性。50%接受新生儿期POA - AH植入的雌性在成年后表现出阴道无周期性，这表明正常促性腺激素释放受到了显著干扰。对雌性性行为的测试表明，POA - AH和腹内侧弓状区域的植入物在雌激素和孕酮预处理后，对脊柱前凸潜伏期或总脊柱前凸持续时间没有显著影响，但确实缩短了最长单次脊柱前凸发作时间。结合其他近期研究，这些发现表明，在仓鼠中，与其他物种一样，雄激素化在位置和对激素暴露的敏感性方面涉及几个独立的过程。
