Christensen L W, Gorski R A
Brain Res. 1978 May 12;146(2):325-40. doi: 10.1016/0006-8993(78)90977-0.
Small pellets of testosterone (T) or estradiol (E2), but not cholesterol (CH), when implanted into the brain of neonatal female rats on day 2 or day 5 of life, produce masculinization of the adult regulation of gonadotropic hormone (GTH) release, female sexual behavior or masculine sexual behavior, specific to the site and time of implantation and the hormone implanted. Site specificity: There appear to be specific neuronal sites where implantation of T or E2 produces independent masculinization of GTH, female sexual behavior or masculine sexual behavior patterns. Implants of T or E2 placed in the dorsal preoptic area (POA) perinatally increase the amount of masculine sexual behavior displayed by adults. On the other hand, the ventromedial hypothalamus (VMH) is the only area in which neonatal implants of T or E2 produce GTH acyclicity in adults. Female sexual behavior is affected in opposite directions by hormonal implants in two different areas. Neonatal implants of T or E2 in the POA increase adult behavioral responsiveness to estradiol benzoate (EB) alone, whereas implants in the VMH decrease adult responsiveness to EB plus progesterone therapy. Temporal specificity: The most effective time for augmenting masculine sexual behavior is before day 5, since hormone implants on that day produce marginal effects on male sexual behavior, whereas day 2 implants in POA results in substantial increases in both mount and intromission patterns. GTH release in masculinized equally well by implants of hormones on either day 2 or day 5. Female sexual behavior is affected only by neonatal implants on day 2. Hormone specificity: Estradiol is as effective as T in masculinizing all three neuroendocrine parameters. In any particular neural site in which T implants produce an alteration in the neuroendocrine response, a similar effect is produced by E2 implants in the same site. It is suggested that independent masculinization of GTH, female sexual behavior and masculine sexual behavior patterns is produced by the action of T and/or E2 on separate neural areas, and that these neural areas may be susceptible to the action of hormones at different times.
在新生雌性大鼠出生后第2天或第5天，将睾酮（T）或雌二醇（E2）而非胆固醇（CH）的小丸植入其大脑，会使成年促性腺激素（GTH）释放调节、雌性性行为或雄性性行为发生雄性化，这取决于植入的部位、时间以及激素种类。部位特异性：似乎存在特定的神经元部位，在这些部位植入T或E2会分别使GTH、雌性性行为或雄性性行为模式发生独立的雄性化。围产期将T或E2植入背侧视前区（POA）会增加成年大鼠表现出的雄性性行为量。另一方面，腹内侧下丘脑（VMH）是唯一在新生期植入T或E2会使成年大鼠GTH无周期性变化的区域。在两个不同区域进行激素植入会对雌性性行为产生相反的影响。在POA进行新生期T或E2植入会增加成年大鼠对单独的苯甲酸雌二醇（EB）的行为反应性，而在VMH植入则会降低成年大鼠对EB加孕酮治疗的反应性。时间特异性：增强雄性性行为的最有效时间是在第5天之前，因为在该日进行激素植入对雄性性行为产生的影响较小，而在POA于第2天植入会使爬跨和插入模式显著增加。在第2天或第5天植入激素对使GTH释放雄性化的效果相同。雌性性行为仅受出生后第2天新生期植入的影响。激素特异性：在使所有三个神经内分泌参数雄性化方面，雌二醇与T的效果相同。在T植入导致神经内分泌反应改变的任何特定神经部位，E2植入同一部位会产生类似效果。有人提出，GTH、雌性性行为和雄性性行为模式的独立雄性化是由T和/或E2对不同神经区域的作用产生的，并且这些神经区域可能在不同时间对激素作用敏感。
