预测患者对华法林的需求量。
Predicting patients' warfarin requirements.
作者信息
Routledge P A, Davies D M, Bell S M, Cavanagh J S, Rawlins M D
出版信息
Lancet. 1977 Oct 22;2(8043):854-5. doi: 10.1016/s0140-6736(77)90786-3.
PMID:72199
Abstract
In 34 patients undergoing anticoagulant therapy with warfarin a close relationship has been observed between the logarithm of the 'Thrombotest' response to a loading dose (10 mg/day for three days) and the maintenance dose required to achieve an anticoagulant response of 8-12% (thrombo-test). This relationship appears to be close enough to enable maintenance dosages to be predicted.
摘要
在34例接受华法林抗凝治疗的患者中，观察到给予负荷剂量（10毫克/天，共三天）后“凝血酶试验”反应的对数与达到8 - 12%抗凝反应（凝血酶试验）所需的维持剂量之间存在密切关系。这种关系似乎足够密切，能够预测维持剂量。
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