Welt S I, Dorminy J H, Jelovsek F R, Crenshaw M C, Gall S A
Obstet Gynecol. 1981 May;57(5):557-65.
A controlled prospective evaluation of pregnancy complicated by chronic hypertension is proposed and preliminary data on population selection and pregnancy outcome are presented. Sixty-three women with evidence of underlying hypertensive disease were followed prospectively throughout pregnancy. Twenty-three patients were followed in a protocol of intensified prenatal care and randomized assignment of antihypertensive agents: placebo, hydralazine, or methyldopa. Forty patients were followed in the high-risk pregnancy clinics at Duke University. The incidence of preeclampsia in the randomized prophylactic antihypertensive group was statistically lower than that in the nonrandomized group (8.7 versus 32.5%; P less than .01). There were no other statistically significant differences between the groups. The 63 hypertensive women had a high incidence of diabetes mellitus diagnosed during pregnancy (49.2%) as compared to the authors' general obstetric population (8.1%).
本文提出了一项关于妊娠合并慢性高血压的对照前瞻性评估，并展示了有关人群选择和妊娠结局的初步数据。对63名有潜在高血压疾病证据的女性进行了整个孕期的前瞻性随访。23名患者按照强化产前护理方案进行随访，并随机分配抗高血压药物：安慰剂、肼屈嗪或甲基多巴。40名患者在杜克大学高危妊娠诊所进行随访。随机预防性抗高血压组的子痫前期发病率在统计学上低于非随机组（8.7%对32.5%；P<0.01）。两组之间没有其他统计学上的显著差异。与作者的普通产科人群（8.1%）相比，这63名高血压女性在孕期被诊断出糖尿病的发生率较高（49.2%）。
