Chandra M, Hoyer J R, Lewy J E
Pediatr Res. 1981 Apr;15(4 Pt 1):340-4. doi: 10.1203/00006450-198104000-00010.
Left (L) renal perfusion with an aminonucleoside of puromycin (PA), was used to produce unilateral proteinuria in 15 rats to examine the mechanisms responsible for renal salt retention in the nephrotic syndrome. Thirteen control rats underwent L renal perfusion with isotonic saline. Animals were studied 8 (group I) or 13 (group II) days after perfusion. Renal perfusion with saline per se did not change the glomerular filtration rate, renal plasma flow, or absolute and fractional excretion of sodium (Na) from the perfused kidney. PA animals showed a significant decrease in glomerular filtration rate from the perfused kidney and a proportional decrease in the absolute excretion of Na from the PA perfused kidney as compared to the right kidney. The fractional excretion of Na was equivalent in the L and R kidneys of the PA animals. The mean absolute Na excretion from the nonproteinuric R kidney of PA rats was almost twice that of the R kidney of the controls. The increased Na excretion by the nonproteinuric kidney of the PA animals compensated for the sodium retention by the proteinuric kidney.
用嘌呤霉素氨基核苷（PA）对15只大鼠进行左肾灌注，以诱导单侧蛋白尿，从而研究肾病综合征中肾脏盐潴留的机制。13只对照大鼠用等渗盐水进行左肾灌注。在灌注后8天（I组）或13天（II组）对动物进行研究。单纯用盐水进行肾灌注不会改变肾小球滤过率、肾血浆流量，也不会改变灌注肾中钠（Na）的绝对排泄量和分数排泄量。与右侧肾脏相比，PA组动物灌注肾的肾小球滤过率显著降低，且PA灌注肾中Na的绝对排泄量成比例降低。PA组动物左、右肾的钠分数排泄量相当。PA大鼠非蛋白尿性右肾的平均绝对钠排泄量几乎是对照组右肾的两倍。PA组动物非蛋白尿性肾增加的钠排泄量补偿了蛋白尿性肾的钠潴留。
