Kida K, Thurlbeck W M
Pediatr Res. 1981 Mar;15(3):269-77. doi: 10.1203/00006450-198103000-00014.
We banded the trachea of 4-wk-old male rats and studied lung growth, lung morphometry, and static pulmonary mechanics 4 wk later. We compared the experimental animals to sham-operated male littermates of the same age, 8-wk-old normal male littermates, and weight-matched rats of a younger age. Tracheal banded animals were smaller and had significantly smaller absolute lung volumes fewer alveoli, larger interalveolar wall distances, and increased alveolar duct size compared to the other groups. Their lung volumes were significantly smaller than were those of weight-matched controls. Air-filled pressure-volume curves from the tracheal ligation group were shifted to the left and upward when expressed as a percentage of total lung capacity or by fitting exponentials to the pressure-volume curves. There was no difference in saline-filled pressure-volume curves. We conclude that tracheal banding slows somatic growth and alters normal lung growth. Loss of elastic recoil appears to be due to alteration of surface forces.
我们对4周龄雄性大鼠的气管进行结扎，并在4周后研究肺生长、肺形态测量以及静态肺力学。我们将实验动物与同龄的假手术雄性同窝幼仔、8周龄正常雄性同窝幼仔以及体重匹配的年轻大鼠进行比较。与其他组相比，气管结扎的动物体型较小，绝对肺容积明显更小，肺泡数量更少，肺泡间隔距离更大，肺泡管尺寸增加。它们的肺容积明显小于体重匹配的对照组。当以总肺容量的百分比表示或通过对压力-容积曲线拟合指数时，气管结扎组的充气压力-容积曲线向左上方移动。充生理盐水的压力-容积曲线没有差异。我们得出结论，气管结扎会减缓身体生长并改变正常的肺生长。弹性回缩力的丧失似乎是由于表面力的改变所致。
