Artru F, Guerin J M, Latarjet J, Deleuze R
Nouv Presse Med. 1981 Apr 11;10(16):1301-4.
Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG. Brain death occurred in 20%. The overall mortality rate was 60%, no death being attributable to treatment; 24% of the patients were able to resume active life. Patients with non-reactive pupils during the early phase of coma were compared with patients of similar ages and neurological symptoms non treated with pentobarbital. In treated patients the incidence of brain death was reduced by 50% and the mortality rate by 25% (p less than 0.05), without increase in deaths from intercurrent complications and in severe sequelae among survivors.
45例因头部受伤而处于深度昏迷的患者接受了戊巴比妥治疗，药物剂量根据维持血清巴比妥酸盐水平在15至25mg/l之间以及脑电图上的短阵爆发抑制期进行调整。20%的患者发生脑死亡。总体死亡率为60%，无死亡归因于治疗；24%的患者能够恢复积极的生活。将昏迷早期瞳孔无反应的患者与年龄和神经症状相似但未接受戊巴比妥治疗的患者进行比较。在接受治疗的患者中，脑死亡发生率降低了50%，死亡率降低了25%（p<0.05），且并发并发症导致的死亡和幸存者中的严重后遗症均未增加。
