Saito T, Takeichi S, Nakajima Y, Yukawa N, Osawa M
Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Japan.
Nihon Hoigaku Zasshi. 1995 Dec;49(6):484-7.
Post-mortem concentration of pentobarbital in the blood and brain of two deceased neurosurgical patients was determined by gas chromatography/mass spectrometry. Patients treated with barbiturate for elevated intracranial pressure after head injury may incur brain death. In the present two cases of brain death a large amount of barbiturate remained in the brain, even when the blood concentration was not detectable, possibly because the blood flow was stagnant in the brain. It is suggested that a patient under barbiturate coma should be given serious consideration as to the determination of brain death, even if barbiturate is negative in the blood.
通过气相色谱/质谱法测定了两名已故神经外科患者血液和大脑中戊巴比妥的死后浓度。头部受伤后接受巴比妥类药物治疗以降低颅内压的患者可能会发生脑死亡。在目前这两例脑死亡病例中，即使血液浓度检测不到，大脑中仍残留大量巴比妥类药物，这可能是因为大脑中的血流停滞。建议即使血液中巴比妥类药物呈阴性，对于处于巴比妥类药物昏迷状态的患者，在判定脑死亡时也应予以认真考虑。
