Hofstädter F
Pathol Res Pract. 1980 Nov;169(3-4):304-22. doi: 10.1016/S0344-0338(80)80009-4.
36 thyroid carcinomas have been studied by means of electron microscopy. The specimens of 12 non-malignant thyroid lesions served as control. All the investigated tumours are composed of mixed populations of tumour cells differentiated in manifold variations. Differentiated carcinomas (follicular, papillary) often show misdifferentiations of the cytoplasm in light microscope, as well as in electron microscope. These misdifferentiations are the hyperplasia of a single cytoplasmatic organella or the hyperplasia of a system of organellas. The hyperplasia can be combined with a normal appearance of the respective organellas or with pathological changes of their morphology. Undifferentiated tumours often show structural remnants of folliculoid differentiation.
已通过电子显微镜对36例甲状腺癌进行了研究。12例非恶性甲状腺病变标本用作对照。所有研究的肿瘤均由多种分化程度各异的肿瘤细胞混合群体组成。分化型癌（滤泡状、乳头状）在光学显微镜和电子显微镜下常表现出细胞质的分化异常。这些分化异常表现为单个细胞质细胞器的增生或细胞器系统的增生。增生可与相应细胞器的正常外观或其形态的病理变化同时存在。未分化肿瘤常显示类滤泡分化的结构残余。
