Experimental infection of Ancylostoma caninum in mice. III. distribution of larvae after repeated exposures to infection.

Different groups of mice were infected with various single or repeated doses of larvae of Ancylostoma caninum. Considerable loss of larvae occurred in the immunised groups when compared with their counterpart unimmunised groups. Larval migration and distribution in the different tissues was less in immunised mice, as most larvae were expelled from the gastrointestinal tract. This resulted in a poor onward larval migration to liver, lungs, brain and muscle regions in immunised groups. The heavily immunised group infected five times was most affected and a significant lesser larval distribution in various organs and muscle region observed.