Thiery M, Parewijck W, Decoster J M
Prostaglandins. 1981 Feb;21(2):207-15. doi: 10.1016/0090-6980(81)90138-6.
In 17 women carrying an anencephalic fetus (3 or them dead) an attempt was made to terminate the pregnancy with either intravaginal suppositories containing 20 mg prostaglandin E2 each or serial intramuscular injections of 250 microgram of 15(S)-15-methyl-prostaglandin F2 alpha. The duration of pregnancy ranged from 18 to 39 weeks (mean: 28.5 weeks). Fifteen women expelled the complete uterine contents after a period ranging from 4:15 to 39:10 h:min (mean: 15:11 h:min) following the initiation of treatment. There were two failures, and in both of these cases labor started spontaneously after cessation of the prostaglandin treatment. No serious complications occurred. The PG treatment induced no changes in routine laboratory values and significant alterations in the mother's vital signs were uncommon. Even though intravaginal prostaglandin E2 and intramuscular 15-methyl-prostaglandin F2 alpha often produced gastro-intestinal side effects, there can be no doubt as to the unique utility of these compounds for the management of anencephalic pregnancies, whatever the duration of gestation and vital status of the fetus.
对17例怀有无脑儿胎儿的孕妇（其中3例胎儿已死亡）进行了妊娠终止尝试，分别采用了每枚含20毫克前列腺素E2的阴道栓剂，或连续肌肉注射250微克的15（S）-15-甲基前列腺素F2α。妊娠持续时间为18至39周（平均：28.5周）。15名妇女在开始治疗后的4小时15分钟至39小时10分钟（平均：15小时11分钟）内排出了全部子宫内容物。有2例失败，在这两例中，前列腺素治疗停止后均自发开始分娩。未发生严重并发症。前列腺素治疗未引起常规实验室值的变化，母亲生命体征的显著改变也不常见。尽管阴道用前列腺素E2和肌肉注射15-甲基前列腺素F2α常产生胃肠道副作用，但无论妊娠持续时间和胎儿生命状态如何，这些化合物在处理无脑儿妊娠方面的独特效用是毋庸置疑的。
