Ientile R, Di Giorgio R M, Rotiroti D, Nistico' G
Res Commun Chem Pathol Pharmacol. 1981 Feb;31(2):241-50.
The effects of cefazolin, given into the III cerebral ventricle at different doses were studied on GABA content, GAD and GABA-T in the brain-stem of young chickens (Gallus domesticus). A dose-dependent fall in GABA content was observed; GABA decrease was evident 15 min after the administration, reached its nadir at 60 min and disappeared at 120 minutes. Glutamate decarboxylase and GABA-transaminase activity were not significantly changed. Present experiments suggest the excitatory and convulsant effects of cefazolin in chicks are related to GABA depletion in the brain-stem.
研究了不同剂量的头孢唑林注入雏鸡（家鸡）第三脑室后对其脑干中γ-氨基丁酸（GABA）含量、谷氨酸脱羧酶（GAD）和GABA转氨酶（GABA-T）的影响。观察到GABA含量呈剂量依赖性下降；给药后15分钟GABA含量明显降低，60分钟时降至最低点，120分钟时消失。谷氨酸脱羧酶和GABA转氨酶活性无明显变化。目前的实验表明，头孢唑林对雏鸡的兴奋和惊厥作用与脑干中GABA耗竭有关。
