Preisig R, Halter F, Bircher J
Schweiz Med Wochenschr. 1981 Feb 28;111(9):297-302.
Since gallstone disease is one of the most frequent gastrointestinal disorders (average incidence 27% in males and 47% in females) it is mandatory for practicing physicians to keep abreast of recent progress in therapy. Thus, present treatment is based on the radiologic pattern of radiolucent (cholesterol) and radioopaque (calcium containing) stones. In the young patient, cholecystectomy is recommended for cholecystolithiasis regardless of type of stones, because this procedure is likely in most cases to provide optimal, definitive results at minimal risk. In the elderly, or when the operative risk is aggravated by accompanying disease, an attempt may be made to dissolve cholesterol stones by oral administration of cheno- or ursodeoxycholic acid. Following 18 months to 2 years of medication, the success rate for complete dissolution is approximately 50%.
由于胆结石病是最常见的胃肠道疾病之一(男性平均发病率为27%,女性为47%),执业医师必须了解治疗方面的最新进展。因此,目前的治疗是基于透光性(胆固醇)结石和不透光性(含钙)结石的放射学特征。对于年轻患者,无论结石类型如何,胆囊结石均建议行胆囊切除术,因为在大多数情况下,该手术可能以最小的风险提供最佳的确定性结果。对于老年人,或当伴随疾病加重手术风险时,可尝试通过口服鹅去氧胆酸或熊去氧胆酸来溶解胆固醇结石。经过18个月至2年的药物治疗,完全溶解的成功率约为50%。