Peroutka S J, Lebovitz R M, Snyder S H
Science. 1981 May 15;212(4496):827-9. doi: 10.1126/science.7221567.
Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.
两种不同的血清素（5-羟色胺）受体，分别命名为血清素1和血清素2，它们分别与氚标记的血清素和氚标记的螺哌啶醇结合。药物在血清素2位点而非血清素1位点的效力，可预测其对“血清素行为综合征”的影响，这表明血清素2位点介导了这些行为。药物效应与鸟嘌呤核苷酸调节之间的有限相关性表明，血清素1位点可能与腺苷酸环化酶相联系。血清素引发的突触抑制和兴奋的药物特异性可能分别反映了血清素1和血清素2受体的相互作用。
