Weis R F, Everett E D, Sprouse R, Elfervig J L
South Med J. 1981 Apr;74(4):482-3. doi: 10.1097/00007611-198104000-00027.
We have described a case of Cryptococcus neoformans endophthalmitis, especially rare in the absence of simultaneous CNS involvement. The key to management appears to lie in early diagnosis, which is difficult because there are multiple causes of uveitis; clinical examination will not establish the specific cause. If clinical improvement is not apparent after several days of nonspecific therapy and other studies have failed to yield a diagnosis, appropriate stains and cultures of vitreal aspirate should be done for fungi and other organisms. Amphotericin B plus 5-fluorocytosine is the treatment of choice, possibly with intravitreal instillation of amphotericin B and vitrectomy.
我们描述了一例新型隐球菌性眼内炎病例，在无同时合并中枢神经系统受累的情况下尤为罕见。治疗的关键似乎在于早期诊断，而这颇具难度，因为葡萄膜炎有多种病因；临床检查无法确定具体病因。如果经过数天的非特异性治疗后临床改善不明显，且其他检查未能得出诊断结果，就应对玻璃体液抽吸物进行针对真菌及其他病原体的适当染色和培养。两性霉素B加5-氟胞嘧啶是首选治疗方法，可能还需玻璃体内注射两性霉素B并进行玻璃体切割术。
