Sonakul D, Pacharee P, Laohapand T, Fucharoen S, Wasi P
Southeast Asian J Trop Med Public Health. 1980 Dec;11(4):516-23.
A new feature has been encountered in review of a large species of autopsy materials of beta-thalassaemia/Hb E disease. Among 43 patients pulmonary arterial obstructive lesions were found in 19 (44%), of which 17 were splenectomised cases. The pulmonary arterial thromboembolism may have been due to circulating platelet aggregates. This newly discovered pathology may be an additional factor contributing toward dyspnoea and heart failure in thalassaemia besides anaemia and cardiac iron deposition. If it is proven that this pulmonary arterial thromboembolism is indeed due to circulating platelet aggregates, preventive measure by administration of drugs reducing platelet aggregation such as aspirin and Persantin may be indicated, especially after splenectomy.
在对大量β地中海贫血/Hb E病尸检材料进行回顾时发现了一个新特征。在43例患者中，19例（44%）发现有肺动脉阻塞性病变，其中17例为脾切除病例。肺动脉血栓栓塞可能是由于循环中的血小板聚集体所致。这一新发现的病理情况可能是除贫血和心脏铁沉积外，导致地中海贫血患者呼吸困难和心力衰竭的另一个因素。如果经证实这种肺动脉血栓栓塞确实是由循环中的血小板聚集体引起的，那么可能需要采取预防性措施，比如使用阿司匹林和潘生丁等减少血小板聚集的药物进行治疗，尤其是在脾切除术后。
