Fucharoen S, Youngchaiyud P, Wasi P
Southeast Asian J Trop Med Public Health. 1981 Mar;12(1):90-3.
Blood gas analysis of arterial blood was performed in 34 patients with beta o-thalassaemia/haemoglobin E disease and homozygous beta o-thalassaemia. Among the 22 splenectomised patients 19 had PaO2 lower than the normal expected value, and 18 of these had PaO2 lower than 80 mmHg. Of the 12 non-splenectomised patients 5 had PaO2 lower than the expected normal value but only in one case it was lower than 80 mmHg. After aspirin or Persantin administration there was a definite rise in the PaO2 in 10 out of 12 patients. The hypoxaemia is believed to occur from increased platelet aggregation leading to pulmonary artery occlusion. The rise of the arterial PaO2 after aspirin administration indicates that the observed hypoxaemia is due to reversible platelet aggregation in the majority of cases.
对34例β地中海贫血/血红蛋白E病患者和纯合子β地中海贫血患者进行了动脉血气分析。在22例脾切除患者中，19例的动脉血氧分压（PaO2）低于正常预期值，其中18例低于80 mmHg。在12例未行脾切除的患者中，5例的PaO2低于预期正常值，但只有1例低于80 mmHg。给予阿司匹林或潘生丁后，12例患者中有10例的PaO2有明显升高。据信，低氧血症是由于血小板聚集增加导致肺动脉阻塞所致。阿司匹林给药后动脉PaO2升高表明，在大多数情况下，观察到的低氧血症是由于可逆性血小板聚集引起的。
