Doillon C, Dureau G, Clendinnen G, Eloy R
Surg Gynecol Obstet. 1981 May;152(5):613-20.
With the use of microsurgical procedures, sequential studies have been done to compare the short and long term outcome of the bile duct and the femoral vein as autogenous bioprostheses of the bile duct. Nonpretreated grafts of both types are associated with an early superficial cell loss, either epithelial or endothelial. An initial biliary sludge resulted with further consequences, that in biliary stasis, lithiasis and biliary cirrhosis. Both grafted ducts became epithelialized but were the site of an extensive inflammatory reaction followed by fibrosis within the underlying connective tissue and retraction of the graft. On the contrary, pretreatment of the grafts by immersion in concentrated glycerol allowed the initial cell shedding to occur before implantation. The process of epithelialization and glandular formation was not altered in these conditions, whereas the inflammatory and fibrotic reaction in the duct wall was reduced or absent.
通过显微外科手术，已进行了一系列研究，以比较胆管和股静脉作为胆管自体生物假体的短期和长期结果。两种类型的未预处理移植物都与早期浅表细胞丢失有关，无论是上皮细胞还是内皮细胞。最初会形成胆泥，并产生进一步的后果，即胆汁淤积、结石形成和胆汁性肝硬化。两个移植的胆管都实现了上皮化，但却是广泛炎症反应的部位，随后在下方的结缔组织内出现纤维化并导致移植物回缩。相反，通过浸入浓缩甘油对移植物进行预处理可使初始细胞脱落发生在植入前。在这些条件下，上皮化和腺体形成过程未改变，而胆管壁的炎症和纤维化反应减少或不存在。
