Doillon C, Dureau G, Chignier E, Clendinnen G, Eloy R
Am J Surg. 1981 Feb;141(2):187-93. doi: 10.1016/0002-9610(81)90154-9.
Mucosal lesions and healing of the common bile duct were analyzed after various chemical and surgical insults in the rat by means of histologic and scanning electron microscopic investigations. Autogenous bile duct replacement is rapidly associated within the first 72 postoperative hours with complete epithelial cell desquamation, and its precocious consequence is biliary sludge. These lesions also occurred when the bile flow was diverted; the extrinsic devascularization and denervation did not produce extensive epithelial cell loss. Heparin perfusion within the biliary tree or the induction by glycerol of epithelial cell loss before bile duct transplantation is suggested in order to avoid extensive biliary sludge after bile duct transplantation.
通过组织学和扫描电子显微镜检查，分析了大鼠在遭受各种化学和手术损伤后胆总管的黏膜病变及愈合情况。自体胆管置换在术后72小时内迅速出现完全上皮细胞脱屑，其早熟后果是胆泥形成。当胆汁流改道时也会出现这些病变；外在的血管离断和去神经支配并未导致广泛的上皮细胞丢失。建议在胆管移植前进行肝内肝素灌注或用甘油诱导上皮细胞丢失，以避免胆管移植后出现广泛的胆泥。
