Makiuchi M, Miyakawa M, Sugenoya A, Furihata R
Surg Gynecol Obstet. 1981 May;152(5):639-41.
A follow-up survey of 447 patients who had undergone a subtotal thyroidectomy was carried out. In this study, 433 patients were observed, and the follow-up period ranged from one year to ten years. The incidence postoperatively of a recurrence and hypothyroidism was 9.6 and 2.3 per cent, respectively. Transient subclinical hypothyroidism was observed in most patients within three to six months after the operation. This state, however, recovered spontaneously to the euthyroid state within one year. Recurrent hyperthyroidism tends to increase with the lapse of years, while permanent hypothyroidism developed during the first or second year after operation. Results of our investigation suggest that the size of the remnant thyroid appears to play the most important role for an expected long term remission, and the optimal weight of the remnant thyroid should be approximately 10 grams. Although the precise mechanism of remission by surgical ablation of the thyroid has not been clarified, surgical treatment is an effective and safe procedure which controls the condition of the patient with thyrotoxicosis.
对447例行甲状腺次全切除术的患者进行了随访调查。本研究观察了433例患者，随访期为1年至10年。术后复发和甲状腺功能减退的发生率分别为9.6%和2.3%。大多数患者在术后3至6个月内出现短暂性亚临床甲状腺功能减退。然而，这种状态在1年内会自发恢复到甲状腺功能正常状态。复发性甲状腺功能亢进症倾向于随着时间的推移而增加，而永久性甲状腺功能减退症则在术后第一年或第二年出现。我们的调查结果表明，残余甲状腺的大小似乎对预期的长期缓解起着最重要的作用，残余甲状腺的最佳重量应约为10克。虽然通过手术切除甲状腺实现缓解的确切机制尚未阐明，但手术治疗是一种有效且安全的方法，可控制甲状腺毒症患者的病情。
