Drumev D, Donev B, Dimitrov K, Dilov P, Dzhurov A
Vet Med Nauki. 1980;17(3):84-92.
We studied the endurance of calves, lambs and pigs as well as the acute, subchronic and chronic toxicity for chickens with regard to bentonite of local origin, extra activated in a physico-chemical way. It was proved that the medicine was rather endurable with calves, lambs and pigs without causing intoxication or death after a single internal introduction in doses respectively 4138, 4130 and 1860 mg/kg t. LD0 of the activated bentonite for the chickens in the case of intra-crop application was over 18000 mg/kg t. During a 33-day extra addition to the fodder of chickens in quantities of 2 and 6% and during a 90-day introduction into concentrations 1, 3 and 5% the activated bentonite and not provoke any changes in the behaviour, overall state and in the clinical biochemical and electrolytic composition (Ca, P, K, Na) of the blood, but it caused suppression of growth ranging from 6 to 27% and brought about a higher expenditure of food for a single growth unit ranging from 4.7 to 12.1%. This was also observed when it was added to the morning ration of pigs in doses 1 and 5% (6 and 30 d/pig) without any influence over the health state of the pigs, but it slowed down growth ranging from 17.2 to 21.3% and a lower utilization of the fodder taken by 19 to 26%.
我们研究了本地膨润土经物理化学方法进一步活化后，对犊牛、羔羊和猪的耐受性以及对鸡的急性、亚慢性和慢性毒性。结果表明，该药物对犊牛、羔羊和猪耐受性较强，单次内服剂量分别为4138、4130和1860毫克/千克体重时，未引起中毒或死亡。经嗉囊给药时，活化膨润土对鸡的半数致死量（LD0）超过18000毫克/千克体重。在鸡饲料中额外添加2%和6%的活化膨润土，持续33天，以及在饲料中添加浓度为1%、3%和5%的活化膨润土，持续90天，均未引起鸡的行为、整体状态以及血液临床生化和电解质成分（钙、磷、钾、钠）的任何变化，但导致生长抑制6%至27%，且单个生长单位的食物消耗量增加4.7%至12.1%。当以1%和5%的剂量添加到猪的早餐日粮中（每头猪6天和30天）时，也观察到了类似情况，对猪的健康状况没有任何影响，但生长速度减慢了17.2%至21.3%，饲料利用率降低了19%至26%。
