Donev B, Kamenska M, Stoianov K, Angelov A K, Petkov I
Vet Med Nauki. 1979;16(9):50-7.
Studies on the acute, subchronic and chronic toxicity of technical tylosine phosphate (TTP) with 50 UI/mg activity, produced by Pharmachim were carried out. It was established that TTP does not cause lethality in white rats following application of 20, in white mice--of 40, in chickens--of 30 and in pigs--of 2 g/kg body weight. Long term application to the rations--of chickens for 40 days, in doses of 20, 40 and 60 g/kg fodder (=1.3 and 5 ED100) and of pigs for 32 days in doses of 2.6 and 10 g/kg fodder (=1.3 and 5 ED100) stimulates gain in weight of both species by 2-11.5% and improves the utilization of nutrition by 4.5-12.5% without any unfavourable effect on the clinical-biochemical composition of the blood and the structure and development of inner organs.
对保加利亚制药化学公司生产的活性为50 UI/mg的工业磷酸泰乐菌素（TTP）进行了急性、亚慢性和慢性毒性研究。结果表明，给白鼠按20 g/kg体重、给小白鼠按40 g/kg体重、给鸡按30 g/kg体重、给猪按2 g/kg体重施用TTP后，均未导致死亡。长期给鸡的日粮中添加TTP（40天，剂量为20、40和60 g/kg饲料，即1.3和5倍的ED100）以及给猪的日粮中添加TTP（32天，剂量为2.6和10 g/kg饲料，即1.3和5倍的ED100），可使两种动物的体重增加2 - 11.5%，营养利用率提高4.5 - 12.5%，且对血液的临床生化成分以及内脏器官的结构和发育均无不利影响。
