Richter K
Virchows Arch A Pathol Anat Histol. 1981;391(2):177-87. doi: 10.1007/BF00437595.
Clinical research into patients with idiopathic chronic pancreatitis points to a possible immunopathogenetic process in a number of cases. In order to examine the behaviour between the exocrine pancreas under the influence of anti-rat-pancreas immune serum produced in rabbits, a 1.00 ml immune serum is administered once a week over a maximum 26 week period into Wistar-rats by intraperitoneal injection. By electrone-microscopy a much reduced production of enzymes apparently takes place, though to differing extent. There is also destruction of the basal membrane of acinocytes: the production of interstitial oedema, the new formation of collagen fibres and the proliferation of connective tissue cells. Under a conventional light microscope the first changes become noticeable after 8-12 weeks of study. These take the form of localised cell decay, deterioration and lysis of acinocytes; and an increasing non-specific inflammation. There is also the new formation of connective tissue. After 20-26 weeks the exocrine pancreas is characterised by reduction of parenchyma, acino-ductal metaplasia, chronic inflammatory infiltrates of differing density, fibrous and irregular calibres of the smaller and larger ducts. The findings are almost identical to the structural changes of chronic idiopathic pancreatitis in human beings. The results support the view of an immuno-pathologic aetiology for human chronic idiopathic pancreatitis.
针对特发性慢性胰腺炎患者的临床研究表明，在许多病例中可能存在免疫发病机制。为了研究家兔产生的抗大鼠胰腺免疫血清作用下外分泌胰腺的变化，每周一次通过腹腔注射将1.00毫升免疫血清注入Wistar大鼠体内，最长持续26周。通过电子显微镜观察发现，酶的产生明显减少，不过程度有所不同。腺泡细胞的基底膜也遭到破坏：出现间质水肿、胶原纤维新生以及结缔组织细胞增殖。在传统光学显微镜下，研究8 - 12周后首次出现明显变化。这些变化表现为腺泡细胞局部性细胞衰变、退化和溶解，以及非特异性炎症加剧。还出现了结缔组织新生。20 - 26周后，外分泌胰腺的特征为实质减少、腺泡导管化生、不同密度的慢性炎症浸润、大小导管纤维性和不规则管径变化。这些发现几乎与人类慢性特发性胰腺炎的结构变化相同。结果支持人类慢性特发性胰腺炎免疫病理病因学的观点。
