Ketai R M, Hull A L
J Fam Pract. 1978 Nov;7(5):1011-4.
Because of persistent evidence that tricyclic antidepressants are generally underprescribed in respect to dosage and duration of treatment, a large group of family physicians attending a postgraduate course were asked specifically about their prescribing habits for these drugs. Their responses were compared to a group of psychiatrists. This study documented a tendency among family physicians, when compared to psychiatrists, to prescribe too low a dosage of tricyclics for treatment, to be hesitant to increase the dosage, and to discontinue maintenance prematurely. The family physicians overwhelmingly expressed the belief that 75 mg per day of imipramine or amitriptyline was sufficient for treatment maintenance, whereas 150 mg per day is ordinarily considered the minimum effective dosage. Proper use of tricyclic medication with a discussion of side effects and potential hazards is presented.
由于一直有证据表明，三环类抗抑郁药在治疗剂量和疗程方面普遍存在处方不足的情况，因此专门询问了参加研究生课程的一大群家庭医生关于这些药物的处方习惯。将他们的回答与一组精神科医生的回答进行了比较。这项研究记录了与精神科医生相比，家庭医生有以下倾向：开三环类药物的治疗剂量过低、不愿增加剂量以及过早停止维持治疗。绝大多数家庭医生表示认为，每天75毫克的丙咪嗪或阿米替林足以维持治疗，而通常认为每天150毫克是最低有效剂量。本文介绍了三环类药物的正确使用方法以及关于副作用和潜在风险的讨论。
