Reuter W, Sauer I, Ries W
Z Alternsforsch. 1980;35(6):453-9.
The longitudinal behavior of serum uric acid was studied by regular determinations made on a total of 195 subjects (of whom 53 were males and 142, females) between 1968 and 1978. The concentration of uric acid showed a significant increase within ten years irrespective of age, sex, and body weight. Nutritional influences, problems of physical and mental activity, therapeutical measures and agents, as well as hormonal alteration are discussed as possible cause thereof. There were no correlation between change in relative weight and uric acid level. Serum cholesterol and uric acid trends showed negative correlations in young men and positive correlations in older men.
通过对1968年至1978年间共195名受试者（其中男性53名，女性142名）进行定期检测，研究了血清尿酸的纵向变化情况。无论年龄、性别和体重如何，尿酸浓度在十年内均显著升高。文中讨论了营养影响、身心活动问题、治疗措施和药物以及激素变化等可能导致这种情况的原因。相对体重的变化与尿酸水平之间没有相关性。血清胆固醇和尿酸趋势在年轻男性中呈负相关，在老年男性中呈正相关。
