Baliarsingh Simant, Sharma Neha
Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.
Clin Lab. 2012;58(5-6):545-50.
Uric acid, the final product of purine catabolism, has been associated with dyslipidemia, most importantly hypertriglyceridemia. But studies on the relation between uric acid and lipid parameters in the Indian population have been minimal.
Relation between serum uric acid and serum lipids in 121 healthy men, aged 34 to 60 years was studied retrospectively. The subjects were stratified according to age and uric acid levels. All biochemical parameters were measured on automated analysers using reagent kits from standard companies.
In men < 45 years in age, those having high serum uric acid levels had a higher serum total cholesterol (p = 0.003), low density lipoprotein cholesterol (p = 0.005), triglycerides (p = 0.02), and very low density lipoprotein cholesterol (p = 0.02) than those having low serum uric acid. Whereas in the > or = 45 year age group when subjects having high serum uric acid were compared to those having low uric acid levels, the only parameters that showed an increase were triglycerides (p = 0.009) and very low density lipoprotein cholesterol (p = 0.008). A statistically significant positive correlation was observed between serum uric acid and serum triglycerides in men of both age groups separately, but between serum uric acid and serum total cholesterol only in the lower age group.
Thus, serum uric acid levels in the normal range might be a good indicator of the level of triglycerides and very low density lipoprotein cholesterol in men encompassing a wide age range but of total cholesterol and low density lipoprotein cholesterol only in men less than 45 years in age.
尿酸是嘌呤分解代谢的终产物，与血脂异常有关，最重要的是与高甘油三酯血症有关。但关于印度人群尿酸与血脂参数之间关系的研究极少。
回顾性研究了121名年龄在34至60岁之间的健康男性血清尿酸与血脂之间的关系。根据年龄和尿酸水平对受试者进行分层。所有生化参数均使用标准公司的试剂盒在自动分析仪上进行测量。
在年龄小于45岁的男性中，血清尿酸水平高的人比血清尿酸水平低的人具有更高的血清总胆固醇（p = 0.003）、低密度脂蛋白胆固醇（p = 0.005）、甘油三酯（p = 0.02）和极低密度脂蛋白胆固醇（p = 0.02）。而在年龄大于或等于45岁的组中，将血清尿酸水平高的受试者与尿酸水平低的受试者进行比较时，仅甘油三酯（p = 0.009）和极低密度脂蛋白胆固醇（p = 0.008）显示升高。在两个年龄组的男性中，分别观察到血清尿酸与血清甘油三酯之间存在统计学上显著的正相关，但仅在较低年龄组中血清尿酸与血清总胆固醇之间存在正相关。
因此，正常范围内的血清尿酸水平可能是广泛年龄范围内男性甘油三酯和极低密度脂蛋白胆固醇水平的良好指标，但仅在年龄小于45岁的男性中是总胆固醇和低密度脂蛋白胆固醇水平的良好指标。
