Eggert W, Schmidt G, Devaux S
Z Urol Nephrol. 1981 Feb;74(2):141-7.
Under the influence of the uraemic plasma a number of changes of the metabolism of red blood cells develop. By means of cross experiments with the help of filtrability, of sulf-haemoglobin formation and the 125-iodine-hippuran intake the influence of the uraemic plasma and of the plasma of healthy persons on the red blood cells of children who undergo a chronic haemodialysis as well as of healthy adults (cross experiments) was examined. The red blood cells of the control persons after an incubation at 37 degrees and 60 or 180 minutes showed approximately the same changes of filtrability, formation of sulf-haemoglobin and 125-iodine-hippuran as the red blood cells of the patients with incubation in the autologous plasma. Disturbances of the filtrability and the formation of sulf-haemoglobin could be proved in the uraemic red blood cells still after reincubation in the normal plasma, though clearly reduced. Only in 125-iodine-hippuran a normalisation could be got. Filtrability and formation of sulf-haemoglobin apparently comprise more complex processes which essentially influence the life span of the red blood cells, whereas the 125-iodine-hippuran value characterizes only a part of the metabolism of the red blood cells, the passive transport of anions.
在尿毒症血浆的影响下，红细胞代谢会发生一系列变化。借助过滤性、硫血红蛋白形成以及125-碘马尿酸摄取的交叉实验，研究了尿毒症血浆和健康人血浆对接受慢性血液透析的儿童以及健康成年人的红细胞的影响（交叉实验）。对照人员的红细胞在37摄氏度下孵育60或180分钟后，其过滤性、硫血红蛋白形成以及125-碘马尿酸的变化与在自体血浆中孵育的患者红细胞大致相同。即使在正常血浆中再孵育后，尿毒症红细胞的过滤性和硫血红蛋白形成仍存在紊乱，尽管明显减轻。只有125-碘马尿酸的值能够恢复正常。过滤性和硫血红蛋白形成显然包含更复杂的过程，这些过程本质上影响红细胞的寿命，而125-碘马尿酸值仅表征红细胞代谢的一部分，即阴离子的被动转运。
