Department of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, HSF III, 8th Floor, 670 West Baltimore Street, Baltimore, MD 21204, USA.
Department of Pediatrics, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, HSF III, 8th Floor, 670 West Baltimore Street, Baltimore, MD 21204, USA.
Crit Care Clin. 2020 Apr;36(2):267-292. doi: 10.1016/j.ccc.2019.12.008. Epub 2020 Feb 11.
Oxygen (O2) delivery, which is fundamental to supporting patients with critical illness, is a function of blood O2 content and flow. This article reviews red blood cell (RBC) physiology and dysfunction relevant to disordered O2 delivery in the critically ill. Flow is the focus of O2 delivery regulation: O2 content is relatively fixed, whereas flow fluctuates greatly. Thus, blood flow volume and distribution vary to maintain coupling between O2 delivery and demand. This article reviews conventional RBC physiology influencing O2 delivery and introduces a paradigm for O2 delivery homeostasis based on coordinated gas transport and vascular signaling by RBCs.
氧气（O2）输送是支持危重病患者的基础，其功能取决于血液 O2 含量和流量。本文综述了与危重病患者 O2 输送障碍相关的红细胞（RBC）生理学和功能障碍。流量是 O2 输送调节的重点：O2 含量相对固定，而流量波动较大。因此，血液流量和分布会发生变化，以维持 O2 输送与需求之间的耦合。本文综述了影响 O2 输送的常规 RBC 生理学，并介绍了基于 RBC 协调的气体运输和血管信号传递的 O2 输送稳态的范例。
