The effect of local methylprednisolone on granulation tissue formation. 1. Effect on the various granulation tissue components.

The effect of locally administered depot preparation of methylprednisolone on granulation tissue formation in the rat was studied. Various connective tissue components were analysed at different times in implanted viscose cellulose sponges. When the corticosteroid was administered at the time of operation, both the accumulation of collagen and development of vascularity was retarded. Methylprednisolone did not affect the number of white cells infiltrating the sponge nor the sponge content of DNA. This mode of drug administration was shown to have mostly local effects.