Hølund B, Junker P, Garbarsch C, Christoffersen P, Lorenzen I
Acta Pathol Microbiol Scand A. 1979 Sep;87A(5):367-74.
A comparison was made between the granulation tissue formation in two different synthetic sponge types. Visella and Ivalon, of different sizes. The granulation tissue formed in the two sponge types did not differ qualitatively, and had the character of wound tissue and inflammatory tissue in man. The rate of tissue formation in the Visella sponges was faster and the tissue was more homogenous than in the Ivalon sponges. Fourteen-day-old Visella implants of either size contained more granulation tissue than Ivalon sponges, probably owing to the smaller pore size of the former material. This may also account for the more frequent occurrence of giant cells in the Visella implants. In contrast to the Visella sponges, the trabeculae of the Ivalon polymer showed calcification and positive staining properties with histological staining procedures, and deformation was frequent among the Ivalon implants. Thin sponges of either type closed in about 21 days, thick ones after about 42 days of implantation. Calculated per 2 cm3 of implant, thin sponges produced more tissue after 14 days of implantation than thick noes. It is concluded that the Visella sponge type is best suitable for this experimental model of inflammation.
对两种不同类型、不同尺寸的合成海绵（Visella和Ivalon）中的肉芽组织形成进行了比较。两种海绵中形成的肉芽组织在质量上没有差异，具有人体伤口组织和炎症组织的特征。Visella海绵中的组织形成速度比Ivalon海绵更快，且组织更均匀。任何一种尺寸的14日龄Visella植入物所含的肉芽组织都比Ivalon海绵多，这可能是由于前者材料的孔径较小。这也可能是Visella植入物中巨细胞更频繁出现的原因。与Visella海绵不同，Ivalon聚合物的小梁在组织学染色程序中显示出钙化和阳性染色特性，并且Ivalon植入物中经常出现变形。任何一种类型的薄海绵在约21天内闭合，厚海绵在植入约42天后闭合。按每2 cm³植入物计算，植入14天后薄海绵产生的组织比厚海绵多。得出的结论是，Visella海绵类型最适合这种炎症实验模型。
