Dehmer G J, Firth B G, Lewis S E, Willerson J T, Hillis L D
Am J Cardiol. 1981 May;47(5):1061-7. doi: 10.1016/0002-9149(81)90213-7.
A nongeometric technique for the determination of left ventricular volumes from the count data derived from gated equilibrium blood pool scans was previously described and validated by the demonstration of an excellent correlation between the derived data and angiographically determined left ventricular volumes. To provide a further prospective evaluation of this method and to validate its ability to determine stroke volume and cardiac output by a technique that is itself independent of geometric assumptions, simultaneous measurements of cardiac output by the thermodilution technique and gated scintigraphy were performed in 21 patients without valve regurgitation or intracardiac shunts. To substantiate the reliability of scintigraphic measurements at high levels of cardiac output, seven patients had multiple measurements of cardiac output at rest and during an infusion of isoproterenol. There was an excellent correlation between thermodilution and scintigraphic values for cardiac output (scan cardiac output = 0.99 thermodilution cardiac output - 0.005 liters/min; n = 31, standard error of the estimate [SEE] = 0.175 liters/min, r = 0.97) as well as between thermodilution and scintigraphic stroke volumes (scan stroke volume = 1.03 thermodilution stroke volume - 2.8 ml; n = 31, SEE = 2.5 ml, r = 0.95). In addition, the relation between scintigraphic and angiographic measurements of left ventricular volumes continued to be excellent: In 15 patients with technically adequate angiograms, scintigraphic left ventricular volume = 0.90 angiographic left ventricular volume + 7 ml (n = 30, SEE = 10 ml, r = 0.91). Thus, this study further validates the nongeometric method of measuring left ventricular volumes with gated scintigraphy and demonstrates its ability to measure left ventricular stroke volume and cardiac output reliably.
先前已描述了一种从门控平衡血池扫描获得的计数数据中确定左心室容积的非几何技术，并通过证明所推导数据与血管造影确定的左心室容积之间具有良好的相关性进行了验证。为了对该方法进行进一步的前瞻性评估，并验证其通过一种本身独立于几何假设的技术来确定每搏输出量和心输出量的能力，对21例无瓣膜反流或心内分流的患者同时进行了热稀释技术和门控闪烁扫描法的心输出量测量。为了证实闪烁扫描测量在高心输出量水平时的可靠性，7例患者在静息状态和静脉输注异丙肾上腺素期间进行了多次心输出量测量。热稀释法和闪烁扫描法测得的心输出量之间具有良好的相关性（扫描心输出量 = 0.99×热稀释心输出量 - 0.005升/分钟；n = 31，估计标准误[SEE] = 0.175升/分钟，r = 0.97），热稀释法和闪烁扫描法测得的每搏输出量之间也具有良好的相关性（扫描每搏输出量 = 1.03×热稀释每搏输出量 - 2.8毫升；n = 31，SEE = 2.5毫升，r = 0.95）。此外，闪烁扫描法和血管造影法测得的左心室容积之间的关系仍然良好：在15例血管造影技术上足够的患者中，闪烁扫描左心室容积 = 0.90×血管造影左心室容积 + 7毫升（n = 30，SEE = 10毫升，r = 0.91）。因此，本研究进一步验证了用门控闪烁扫描法测量左心室容积的非几何方法，并证明了其可靠测量左心室每搏输出量和心输出量的能力。
