Burow R D, Wilson M F, Heath P W, Corn C R, Amil A, Thadani U
J Nucl Med. 1982 Sep;23(9):781-5.
Using a method for determination of absolute volumes, including correcting for attenuation, we have explored the ability of the method to determine stroke volume in humans by radionuclide techniques. Thermodilution cardiac output determinations and multigated equilibrium blood-pool scintigraphy in the LAO view were performed simultaneously in twenty patients in which no evidence of intracardiac shunts or valvular disease was present. The correlation was good between the attenuated radionuclide and thermodilution stroke volume (r = 0.80, s.e.e. of estimate = 12 ml; SVtd = 2.31 x SVr + 18 ml). When correction for attenuation was made, the correlation improved (r = 0.96, s.e.e. = 6 ml) and approached the line of identity (SVtd = 0.99 x SVr + 1.2 ml). The correlation was also good between radionuclide cardiac output, corrected for attenuation, and the thermodilution cardiac output (r = 0.89, s.e.e. = 0.36 l/min; COtd = 0.86 x COr + 0.67 l/min). Thus our method of correction for attenuation in the determination of absolute left-ventricular volumes has been shown to provide a reliable, noninvasive means of calculating stroke volume and cardiac output in humans, without the use of geometric assumptions or regression equations.
我们采用一种绝对容积测定方法，包括对衰减进行校正，探讨了该方法通过放射性核素技术测定人体每搏输出量的能力。对20例无心脏内分流或瓣膜疾病证据的患者，同时进行热稀释法心输出量测定和左前斜位多门控平衡血池闪烁显像。衰减后的放射性核素每搏输出量与热稀释法每搏输出量之间相关性良好（r = 0.80，估计标准误 = 12 ml；SVtd = 2.31×SVr + 18 ml）。进行衰减校正后，相关性得到改善（r = 0.96，标准误 = 6 ml），并接近恒等线（SVtd = 0.99×SVr + 1.2 ml）。经衰减校正后的放射性核素心输出量与热稀释法心输出量之间相关性也良好（r = 0.89，标准误 = 0.36 l/min；COtd = 0.86×COr + 0.67 l/min）。因此，我们在测定绝对左心室容积时的衰减校正方法已被证明可提供一种可靠的、非侵入性的方法来计算人体的每搏输出量和心输出量，无需使用几何假设或回归方程。
