Bradbury M W, Cserr H F, Westrop R J
Am J Physiol. 1981 Apr;240(4):F329-36. doi: 10.1152/ajprenal.1981.240.4.F329.
Lymph from the jugular lymph trunks of anesthetized rabbits has been continuously collected and radioiodinated albumin (RISA) therein estimated after microinjection of 1 microliter of 131I-albumin into the caudate nucleus, after single intraventricular injections, and during intraventricular infusions. Comparison of lymph at 7 and 25 h after intracerebral microinjection with efflux of radioactivity from whole brain suggests that about 50% of cleared radioactivity goes through lymph. Concentrations, normalized to cerebrospinal fluid (CSF), were much higher in lymph and retropharyngeal nodes after brain injection than after CSF injection or infusion. Also after brain injection, lymph and nodes contained more activity on injected side in contrast to lack of laterality after CSF administration. Calculation suggests that less than 30% of RISA cleared from brain can do so via a pool of well-mixed CSF. Analysis of tissues is compatible with much RISA draining by bulk flow via cerebral perivascular spaces plus passage from subarachnoid space of olfactory lobes into submucous spaces of nose and thus to lymph.
在对麻醉兔的颈淋巴干进行淋巴液的持续收集后，于尾状核微量注射1微升¹³¹I - 白蛋白、单次脑室内注射以及脑室内输注期间，对其中的放射性碘标记白蛋白（RISA）进行了估算。将脑内微量注射后7小时和25小时的淋巴液与全脑放射性外流进行比较，结果表明，约50%的清除放射性通过淋巴液排出。与脑脊液注射或输注后相比，脑内注射后淋巴液和咽后淋巴结中相对于脑脊液（CSF）标准化后的浓度要高得多。同样在脑内注射后，与脑脊液给药后缺乏侧别性相反，淋巴液和淋巴结在注射侧的活性更高。计算表明，从脑中清除的RISA中，通过充分混合的脑脊液池排出的比例不到30%。组织分析结果表明，大量RISA通过脑周血管间隙的整体流动排出，再加上从嗅叶蛛网膜下腔进入鼻黏膜下间隙进而进入淋巴液。
