Moseley H S, Thomas L R, Everts E C, Stevens K R, Ireland K M
Am J Surg. 1981 May;141(5):522-5. doi: 10.1016/0002-9610(81)90037-4.
Sequential intraarterial chemotherapy using bleomycin and methotrexate followed by high dose radiation and surgery was evaluated in 10 patients with stage III and IV squamous carcinomas of the maxillary sinus. Seven of 10 patients had extensive tumor necrosis in the surgical specimen, and no evidence of residual tumor was found in 4 of these patients. After a median follow up period of 24 months, there has been only one local recurrence in resected patients. Three patients died from pulmonary metastases. Although many unanswered questions remain regarding the efficacy of triple therapy for maxillary sinus malignancy, these results are encouraging and establish that surgical resection and healing are not compromised by preoperative chemotherapy and radiation.
对10例III期和IV期上颌窦鳞状细胞癌患者进行了评估，采用博来霉素和甲氨蝶呤序贯动脉内化疗，随后进行高剂量放疗和手术。10例患者中有7例手术标本出现广泛肿瘤坏死，其中4例未发现残留肿瘤迹象。中位随访期24个月后，接受手术切除的患者仅出现1例局部复发。3例患者死于肺转移。尽管关于上颌窦恶性肿瘤三联疗法的疗效仍有许多未解决的问题，但这些结果令人鼓舞，并表明术前化疗和放疗不会影响手术切除和愈合。
