Di Perri T, Forconi S, Guerrini M, Pecchi S, Pieragalli D, Cappelli R, Acciavatti A
Angiology. 1981 Apr;32(4):257-65. doi: 10.1177/000331978103200406.
The infusion of isoxsuprine was followed by an increase of heart rate and calf blood flow and by a decrease of arterial diastolic pressure and blood viscosity both in normal controls and patients with peripheral obstructive arterial disease. The pre-treatment with a non-selective beta adrenoceptor blocker (propranolol) canceled all the isoxsuprine-dependent changes, while the pre-treatment with a selective beta adrenoceptor blocker (metoprolol) abolished only tachycardia and did not influence the increase of calf blood flow and the decrease of blood viscosity. These findings indicate the different role of vascular beta receptors in the regulation of muscular blood flow and suggest the pharmacologic possibility to unmask the beta2-dependent vasodilation.
在正常对照组和外周阻塞性动脉疾病患者中，输注异舒普林后心率和小腿血流量增加，动脉舒张压和血液粘度降低。用非选择性β肾上腺素能受体阻滞剂（普萘洛尔）预处理可消除所有依赖异舒普林的变化，而用选择性β肾上腺素能受体阻滞剂（美托洛尔）预处理仅消除心动过速，不影响小腿血流量增加和血液粘度降低。这些发现表明血管β受体在调节肌肉血流量中的不同作用，并提示了揭示β2依赖性血管舒张的药理学可能性。
