Eyre P, Boulard C, Deline T
Am J Vet Res. 1981 Jan;42(1):25-8.
Soluble toxin of Hypoderma lineatum injected IV induced a severe cardiorespiratory shock syndrome in calves. Intradermal injection of the toxin caused well-defined, edematous wheals comparable with those produced by histamine. Treatment of calves with famphur (organophosphate insecticide; poured on the skin of the calves 24 hours before injection of toxin) did not increase the severity of the effects of the toxin. Treatment of calves with phenylbutazone (20 mg/kg) 20 minutes before injection of toxin protected the calves against the systemic shock syndrome and the local inflammatory reaction. Apparently, the neurotoxic mechanism of the organophosphate insecticide is independent of the action of the Hypoderma toxin per se. Phenylbutazone can control the effects of the Hypoderma toxin.
皮下蝇蛆线虫可溶性毒素经静脉注射可在犊牛中诱发严重的心肺休克综合征。皮内注射该毒素会引起界限分明的水肿性风团，与组胺产生的风团类似。用氨磷汀（有机磷杀虫剂；在注射毒素前24小时浇在犊牛皮肤上）处理犊牛并未增加毒素作用的严重程度。在注射毒素前20分钟用保泰松（20毫克/千克）处理犊牛可保护犊牛免受全身休克综合征和局部炎症反应的影响。显然，有机磷杀虫剂的神经毒性机制独立于皮下蝇蛆毒素本身的作用。保泰松可控制皮下蝇蛆毒素的作用。
