Wheat L J, Slama T G, Eitzen H E, Kohler R B, French M L, Biesecker J L
Ann Intern Med. 1981 Mar;94(3):331-7. doi: 10.7326/0003-4819-94-3-331.
An outbreak of histoplasmosis estimated to involve more than 100,000 residents in Indianapolis, Indiana, occurred between September 1978 and August 1979. In the 435 cases evaluated, 52% of the patients were between 15 and 34 years old, and 63% were black. Fifteen patients died, and 46 progressive disseminated infection. Twenty-four patients had pericarditis, and 26 had rheumatologic syndromes. Unusual manifestations that occurred in 18 patients included esophageal and vocal cord ulcers, parotitis, adrenal insufficiency, uveitis, fibrosing mediastinitis, interstitial nephritis, intestinal lymphangiectasia, and epididymitis. The highest attack rate was in the central part of the city, which is a densely populated, disproportionately black section. The source of the outbreak has not been proved by positive culture results; two sites, however, were suspected on an epidemiologic basis.
1978年9月至1979年8月期间，印第安纳州印第安纳波利斯市爆发了组织胞浆菌病，估计涉及10万多名居民。在评估的435例病例中，52%的患者年龄在15至34岁之间，63%为黑人。15例患者死亡，46例为进行性播散性感染。24例患者患有心包炎，26例患有风湿综合征。18例患者出现的不寻常表现包括食管和声带溃疡、腮腺炎、肾上腺功能不全、葡萄膜炎、纤维性纵隔炎、间质性肾炎、肠道淋巴管扩张和附睾炎。发病率最高的是市中心，这是一个人口密集、黑人比例过高的地区。此次疫情的源头尚未通过阳性培养结果得到证实；然而，根据流行病学调查怀疑有两个地点。
