Tabatabai M, Vessal M, Cohanim N
Ann Parasitol Hum Comp. 1980 Sep-Oct;55(5):503-10. doi: 10.1051/parasite/1980555503.
The effects of intravenous administration of the saline extract of the ovine hydatid cyst scoleces on the cardiovascular and respiratory systems were studied in sodium pentobarbital-anesthesized sheep. Scoleces were obtained from the lung hydatid cysts of freshly slaughtered sheep, sonicated in physiologic saline and centrifuged to recover the extract in the supernatant fluid. Administration of 1-4 ml of the saline extract resulted in hypotension, shallow rapid respiration, slight elevation of the central venous pressure and transient electrocardiographic changes. Pretreatment of the animals with atropine, 1 mg/kg S.C., or with the antihistamine antazoline, 5 mg/kg I.V., did not block the responses to the saline extract of hydatid cyst scoleces. Pretreatment with compound 48/80, a histamine releaser, abolished the reactions to the administration of the scoleces extract. It is concluded that ovine hydatid scoleces extract has profound cardiovascular and respiratory effects, and that histamine release seems to be involved in the induction of responses to the extract.
在戊巴比妥钠麻醉的绵羊中，研究了静脉注射绵羊包虫囊肿头节生理盐水提取物对心血管和呼吸系统的影响。头节取自刚宰杀绵羊的肺包虫囊肿，在生理盐水中超声处理后离心，以回收上清液中的提取物。注射1 - 4毫升生理盐水提取物会导致低血压、浅快呼吸、中心静脉压略有升高以及短暂的心电图变化。用1毫克/千克皮下注射阿托品或5毫克/千克静脉注射抗组胺药安他唑啉对动物进行预处理，并未阻断对包虫囊肿头节生理盐水提取物的反应。用组胺释放剂48/80进行预处理可消除对头节提取物给药的反应。结论是，绵羊包虫头节提取物具有深远的心血管和呼吸作用，组胺释放似乎参与了对该提取物反应的诱导。
