Tabatabai M, Ismaili M H, Nazarian I, Daneshbod K
Br J Exp Pathol. 1974 Feb;55(1):33-7.
The pathophysiological changes produced by intravenous administration of ovine hydatid fluid were studied in 40 sodium pentobarbitone-anaesthetized sheep. Hydatid fluid was obtained from the lung and liver cysts of freshly-slaughtered sheep. Fifty per cent of the animals died following intravenous injection of 5-10 ml hydatid fluid. In the latter group, postmortem examination revealed a great amount of mucus in the lower airway, intra-alveolar oedema and haemorrhage, congestion of the pulmonary capillaries and peribronchiolar vessels and of the central sinusoids of the liver. Eighty per cent of the animals (including those which died) developed hypotension and respiratory alterations such as transient apnoea and/or rapid respiration to hydatid fluid administration. The 20% non-reactive animals manifested low blood pressure and respiratory changes when they were reinjected hydatid fluid 48 hours or more after the first test. Pretreatment with the antihistamine chlorpheniramine substantially reduced the fall in blood pressure in 3 out of 8 reactive sheep. Atropine pretreatment failed to block the reactions to hydatid fluid. The responses brought about in sheep by hydatid fluid administration may be due to antigen-antibody reactions or due to pharmacological properties of the cyst fluid.
在40只戊巴比妥钠麻醉的绵羊中研究了静脉注射羊包虫液所产生的病理生理变化。包虫液取自刚宰杀绵羊的肺和肝囊肿。静脉注射5 - 10毫升包虫液后，50%的动物死亡。在后一组中，尸检发现下呼吸道有大量黏液、肺泡水肿和出血、肺毛细血管和细支气管周围血管以及肝中央静脉窦充血。80%的动物（包括死亡的动物）在注射包虫液后出现低血压和呼吸改变，如短暂呼吸暂停和/或呼吸急促。20%无反应的动物在首次试验48小时或更长时间后再次注射包虫液时出现低血压和呼吸变化。用抗组胺药氯苯那敏预处理可使8只反应性绵羊中的3只血压下降幅度显著降低。阿托品预处理未能阻断对包虫液的反应。给绵羊注射包虫液所引起的反应可能是由于抗原 - 抗体反应或由于囊液的药理特性。
