Ceruti T, Biazzi E, D'Avossa I, Pennacchio A, Santini F
Arch Sci Med (Torino). 1980 Apr-Jun;137(2):221-4.
The in vitro activity of phosphomycin has been compared with other antibiotics in 1703 bacterial strains isolated from pathological specimens sent to the Laboratory from various divisions of the hospital. Results were first class on both gram-positive and gram-negative flora. It was in first place as regards staphylococcus (97.4% sensitive strains), citrobacter (68.6%), proteus mirabilis (73.1%), indole positive proteus (48.2%). It also predominated in pseudomonas (54.6%) and E. coli (86.7%). In view of the fact that gram-negative infections are taking on a predominant position within the hospital environment, it is considered that phosphomycin should be rightfully included among the antibacterial drugs in routine use.
已将磷霉素的体外活性与其他抗生素在从医院各科室送至实验室的病理标本中分离出的1703株细菌菌株中进行了比较。结果在革兰氏阳性和革兰氏阴性菌群中均为一流。在葡萄球菌(97.4%敏感菌株)、柠檬酸杆菌(68.6%)、奇异变形杆菌(73.1%)、吲哚阳性变形杆菌(48.2%)方面位居首位。在假单胞菌(54.6%)和大肠杆菌(86.7%)中也占主导地位。鉴于革兰氏阴性感染在医院环境中占据主导地位,认为磷霉素理应被纳入常规使用的抗菌药物之中。