[In vitro antibacterial activity of fosfomycin].
作者信息
Giola L, Rizzu D, Zanetti S
出版信息
G Batteriol Virol Immunol. 1979 Jan-Jun;71(1-6):34-40.
PMID:385409
Abstract
We have studied the "in vitro" antibacterial activity of phosphonomycin against 93 freshly isolated bacterial strains. Phosphonomycin posses a good activity mainly against Gram positive bacteria. A marked increase in the antibacterial activity "in vitro" is obtained when phosphonomycin is combined with other antibitoics having a similar mechanism of action (i.e. inhibition of cell-wall synthesis). We have also determined the frequency of phosphonomycin-resistant mutants in some of the strains tested for antibacterial activity. High frequency of resistant strains have found in Klebsiella spp.
摘要
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